Cheap flights from San Francisco to South America

Travel > South America

Check our current prices for flights from San Francisco to South America. Please note that we also give you historical search data for this city connection. These are all airfares that people found in the past, in order to find more current flight information from San Francisco to South America, you will need to run a search below.

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From $647 / RT details

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Cheap Medellin airfares from $647/RT are provided by Cheapoair.com. Outbound flight is leaving on 04/05/2025, 11:08 pm from San Francisco Intl (SFO) airport and arrives at Medellin Cordova (MDE) at 12:35 am. The flight time is 1 hours and 27 minutes. The Returning flight departes on 04/14/2025, 02:15 pm (other return dates are also available). Date posted: 07 Feb 2025

Price evolution for flights From San Francisco To South America

Recent Deals on Flights from San Francisco to South America:Roundtrip / Oneway

• $647 Multiple Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Medellin, CO (MDE)	04/05/2025	11:08 pm
  Medellin, CO (MDE)	San Francisco, CA (SFO)	04/14/2025	02:15 pm

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• $668 Multiple Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Medellin, CO (MDE)	04/05/2025	06:00 am
  Medellin, CO (MDE)	San Francisco, CA (SFO)	04/14/2025	02:15 pm

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• $695 Lan Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Lima, PE (LIM)	04/07/2025	12:55 pm
  Lima, PE (LIM)	San Francisco, CA (SFO)	04/23/2025	12:50 am

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• $788 Avianca Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	04/23/2025	02:10 pm
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	05/07/2025	03:50 am

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• $810 Avianca Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	04/22/2025	02:20 pm
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	05/07/2025	03:15 am

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• We are sorry but currently there are no oneway offers for flights from San Francisco to South America.
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