Cheap flights from San Francisco to South America
Travel > South America
Travel tip: I was there 5 years ago, the people is werry friendly, they make you part of their family, is so hard to forget people like them!Check our current prices for flights from San Francisco to South America. Please note that we also give you historical search data for this city connection. These are all airfares that people found in the past, in order to find more current flight information from San Francisco to South America, you will need to run a search below.
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Cheap Guayaquil airfares from $977/RT are provided by Cheapoair.com. Outbound flight is leaving on 07/01/2025, 02:20 pm from San Francisco Intl (SFO) airport and arrives at Guayaquil Bolivar (GYE) at 11:20 pm. The flight time is 9 hours and 0 minutes. The Returning flight departes on 07/15/2025, 06:30 pm (other return dates are also available). Date posted: 16 Feb 2025
Price evolution for flights From San Francisco To South America

Recent Deals on Flights from San Francisco to South America:Roundtrip / Oneway
- $977
Avianca Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 07/01/2025 02:20 pm Guayaquil, EC (GYE) San Francisco, CA (SFO) 07/15/2025 06:30 pm - $989
Lan Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Santiago, CL (SCL) 07/02/2025 01:00 pm Santiago, CL (SCL) San Francisco, CA (SFO) 07/08/2025 08:40 pm - $1093
Lan Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 07/01/2025 05:15 pm Guayaquil, EC (GYE) San Francisco, CA (SFO) 07/15/2025 08:40 pm - $1437
Multiple Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Santiago, CL (SCL) 07/02/2025 02:30 am Santiago, CL (SCL) San Francisco, CA (SFO) 07/08/2025 08:40 pm - We are sorry but currently there are no oneway offers for flights from San Francisco to South America.
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